Freund

Powder coating has emerged as a promising approach for the production of modified-release coatings, enabling reduced water consumption and shorter processing times compared with conventional spray-coating techniques. Because powder-deposited polymer layers are inherently more porous, an appropriate curing step is crucial to promote particle coalescence, ensure the formation of a continuous film, and achieve stable and reproducible drug-release performance. In this context, curing temperature and duration are critical process parameters influencing film integrity and release behavior.
Accordingly, this study investigated the powder coating of paracetamol-loaded pellets in a tangential-spray fluid-bed system, with the aim of identifying curing conditions that ensure robust film formation and reliable prolonged-release properties.