Process development scientists study the efficacy of using near-infrared spectroscopy for inline, real-time measurement of product moisture during two different wet granulation methods.

Figure 3: Filter photometer placement in the expansion chamber of the GXR-35 rotor.NIR spectroscopy provided significant advantages over offline moisture measurement in terms of time for sample analysis without a drop off in accuracy. In this study, repeatable moisture curves for a placebo product and an APAP product were produced and validated. The calibration data can be programmed into an NIR filter photometer, which in turn can read out real time moisture data from the product without the need for invasive or disruptive sampling.

Read the article here: Inline moisture endpoint detection

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