Dry Powder Application of Acetaminophen to Multi-Particulates Utilizing a Modified Wurster Spray Gun System

Bottom Spray Wurster technology is commonly used in the pharmaceutical industry as a method for applying active and functional coatings to various multi-particulate substrates. For medium to high drug load applications this technology often becomes complicated when processes require large volumes of dilute solutions or poorly soluble API’s require organic solvents. Large suspension volumes force long duration spray times, can be subject to sedimentation with solution line and spray gun problems leading to agglomeration of substrate particles.

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