Controlled Release Coatings of Ethylcellulose on Drug Loaded Multiparticulates Comparison of Rotor Dry Layering with Wurster Bottom Spray Process

Spray coatings of ethylcellulose for controlled release on multi-particulate dosage forms are common in the pharmaceutical industry, but can be disadvantageous because of long process times, need for organic solvent capabilities, and particulate agglomeration. This study highlights the advantages of a rotor dry powder layering process in overcoming these deficiencies by comparing performance, productivity and cost to solvent based Wurster coating and aqueous-based Wurster coating.

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