High Shear Granulation of Extended Release Tablets Containg Carbopol 971P NF Polymer in Top vs Bottom Drive Mixers

To evaluate aqueous granulation of guaifenesin formulations containing high level of Carbopol® 971P NF polymer (20% w/w) in pilot-scale top-drive vs. bottom-drive granulators, and compare the properties of the granules, tablets obtained by the two processes.

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